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Frederick W K Tam Selected Research

Syk Kinase

1/2022Inhibition of spleen tyrosine kinase decreases donor specific antibody levels in a rat model of sensitization.
11/2020A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury.
6/2020A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic.
1/2020Spleen tyrosine kinase inhibition is an effective treatment for established vasculitis in a pre-clinical model.
1/2018Role of the Spleen Tyrosine Kinase Pathway in Driving Inflammation in IgA Nephropathy.
7/2015Correlation of disease activity in proliferative glomerulonephritis with glomerular spleen tyrosine kinase expression.
10/2012Spleen tyrosine kinase is important in the production of proinflammatory cytokines and cell proliferation in human mesangial cells following stimulation with IgA1 isolated from IgA nephropathy patients.
2/2010A spleen tyrosine kinase inhibitor reduces the severity of established glomerulonephritis.

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Frederick W K Tam Research Topics

Disease

22Glomerulonephritis
01/2020 - 11/2001
12Inflammation (Inflammations)
12/2019 - 05/2005
9Nephritis
02/2018 - 11/2001
7Proteinuria
04/2019 - 11/2001
6Vasculitis (Vasculitides)
12/2021 - 11/2004
6IGA Glomerulonephritis (IGA Nephropathy)
04/2019 - 11/2006
6Fibrosis (Cirrhosis)
04/2019 - 05/2005
5Kidney Diseases (Kidney Disease)
01/2020 - 05/2009
5Renal Insufficiency (Renal Failure)
12/2019 - 05/2009
5Diabetic Nephropathies (Diabetic Nephropathy)
05/2017 - 07/2009
4Necrosis
07/2015 - 11/2001
3Anemia
10/2022 - 05/2009
3Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
12/2021 - 11/2004
3Disease Progression
01/2020 - 12/2009
3Hypertension (High Blood Pressure)
11/2015 - 01/2013
3Weight Loss (Weight Reduction)
11/2013 - 01/2011
2Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
11/2020 - 06/2020
2Acute Lung Injury
11/2020 - 06/2020
2Atrophy
04/2019 - 07/2015
2Sepsis (Septicemia)
01/2018 - 01/2014
2Acute Kidney Injury (Acute Renal Failure)
01/2018 - 01/2018
2Peritonitis
01/2018 - 05/2007
2Albuminuria
11/2015 - 10/2011
2Hypoxia (Hypoxemia)
11/2015 - 01/2014
2Lupus Nephritis
07/2015 - 01/2011
2Peritoneal Fibrosis
09/2014 - 12/2010
2Body Weight (Weight, Body)
07/2013 - 01/2011
1Autoimmune Diseases (Autoimmune Disease)
01/2022
1Nephrotic Syndrome (Syndrome, Nephrotic)
01/2022
1Diabetes Mellitus
01/2021
1Lung Injury
06/2020
1Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
06/2020
1Lung Diseases (Lung Disease)
06/2020
1COVID-19
06/2020
1Autosomal Dominant Polycystic Kidney (ADPKD)
01/2020
1Systemic Vasculitis
01/2020
1Hereditary Nephritis (Alport Syndrome)
12/2019
1Segmental glomerulosclerosis
04/2019
1Venous Thrombosis (Deep-Vein Thrombosis)
01/2019
1Venous Thromboembolism
01/2019
1Microscopic Polyangiitis
11/2018
1Mitochondrial Diseases (Mitochondrial Disease)
01/2018

Drug/Important Bio-Agent (IBA)

9CytokinesIBA
12/2019 - 11/2004
8Syk KinaseIBA
01/2022 - 02/2010
8Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
12/2021 - 11/2006
7CreatinineIBA
01/2021 - 05/2005
7Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
01/2020 - 11/2004
7Purinergic P2X7 ReceptorsIBA
12/2019 - 02/2007
6fostamatinibIBA
11/2020 - 02/2010
5Proteins (Proteins, Gene)FDA Link
01/2022 - 07/2002
4Biomarkers (Surrogate Marker)IBA
06/2020 - 01/2017
3IronIBA
10/2022 - 05/2009
3AutoantibodiesIBA
01/2022 - 10/2014
3ProdrugsIBA
01/2018 - 02/2010
3Adenosine Triphosphate (ATP)IBA
07/2014 - 02/2007
3ChemokinesIBA
07/2013 - 11/2004
2Ferritins (Ferritin)IBA
10/2022 - 05/2009
2ErythropoietinFDA Link
10/2022 - 05/2009
2Rituximab (Mabthera)FDA Link
12/2021 - 12/2013
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
12/2021 - 11/2018
2GlucocorticoidsIBA
12/2021 - 09/2015
2AlbuminsIBA
01/2021 - 10/2011
2Peroxidase (Myeloperoxidase)IBA
01/2020 - 11/2018
2CollagenIBA
12/2019 - 05/2017
2InflammasomesIBA
12/2019 - 01/2014
2Immunoglobulin G (IgG)IBA
11/2018 - 02/2010
2Adrenal Cortex Hormones (Corticosteroids)IBA
11/2018 - 01/2018
2Macrophage Migration-Inhibitory FactorsIBA
02/2018 - 07/2013
2Protein Isoforms (Isoforms)IBA
02/2018 - 09/2015
2salicylhydroxamic acid (SHAM)IBA
01/2018 - 01/2011
2Fibronectins (Fibronectin)IBA
09/2016 - 01/2011
2Dialysis SolutionsIBA
09/2014 - 05/2007
2Interleukin-11 (Interleukin 11)IBA
01/2011 - 11/2001
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2010 - 05/2005
2HepcidinsIBA
03/2010 - 05/2009
2Messenger RNA (mRNA)IBA
06/2009 - 02/2007
1Hemoglobins (Hemoglobin)IBA
10/2022
1Mucin-1 (CA 15-3 Antigen)IBA
06/2020
1Pharmaceutical PreparationsIBA
06/2020
1RNA (Ribonucleic Acid)IBA
01/2020
1MicroRNAs (MicroRNA)IBA
01/2020
1OxalatesIBA
12/2019
1galactosyl-deficient IgA1IBA
04/2019
1Immunoglobulins (Immunoglobulin)IBA
04/2019
1Galactose (Galactopyranose)FDA LinkGeneric
04/2019
1tinostamustineIBA
11/2018
1Alkylating AgentsIBA
11/2018
1AutoantigensIBA
11/2018
1Histone Deacetylase InhibitorsIBA
11/2018
1Oxygen (Dioxygen)IBA
01/2018
1NAD (NADH)IBA
01/2018
1Purinergic Receptors (Receptors, Purine)IBA
01/2018
1Lactic Acid (Lactate)FDA LinkGeneric
01/2018
1Serum AlbuminIBA
01/2018

Therapy/Procedure

6Therapeutics
11/2018 - 11/2004
3Peritoneal Dialysis
09/2014 - 05/2007
3Bariatric Surgery
11/2013 - 01/2011
2Renal Dialysis (Hemodialysis)
10/2022 - 07/2009
2Gastric Bypass (Roux-en-Y Gastric Bypass)
07/2013 - 01/2011
1Plasma Exchange
12/2021